Albumin Metabolism

Albumin metabolism in rheumatoid arthritis.

It is now established that in rheumatoid arthritis changes are not confined only to the joints and the term 'rheumatoid disease' is employed to implicate the involvement of other organs and tissues. It would be helpful to have an index of the severity of the nonarticular involvement and several factors have been investigated from this point of view including the erythrocyte sedimentation rate, ...

Alterations in Albumin Metabolism after Serum and Albumin Infusions.

Albumin-deficient mouse models for studying metabolism of human albumin and pharmacokinetics of albumin-based drugs

Serum albumin is the major determinant of blood colloidal osmotic pressure acting as a depot and distributor of compounds including drugs. In humans, serum albumin exhibits an unusually long half-life mainly due to protection from catabolism by neonatal Fc receptor (FcRn)-mediated recycling. These properties make albumin an attractive courier of therapeutically-active compounds. However, pharma...

Albumin metabolism in patients with Whipple's disease.

When malabsorption develops during the course of Whipple's intestinal lipodystrophy, it is often accompanied by hypoalbuminemia. Among 53 case reports published between 1951 and 1964 for which values of the concentration of albumin in the serum were presented, there were 43 values below 3.5 g per 100 ml (Figure 1). A decrease in the concentration of albumin in the serum may be due to dilution o...

Albumin metabolism in patients with lymphoma.

Most patients with lymphoma have a reduced serum albumin concentration, often despite adequate nutrition and without evident liver disease or urinary protein loss (1-6). The etiology of this hypoalbuminemia is not clear. Possible causes include dilutional hypoalbuminemia, decreased albumin synthesis, increased albumin catabolism within the body, or excessive loss of albumin from the body throug...